Contact Us

Scientists Find Causes for Gender Differences in Liver Cancer

Thinkstock

Scientists have determined why men develop liver cancer at a higher rate than women.Men are four times more likely to develop liver cancer compared to women, due to the sex hormones androgren, the male sex hormone, and estrogen, the female sex hormone.

Researchers at the University of Pennsylvania recently discovered the reason estrogen hormones prevents against liver cancer and androgen hormones increase the risk of liver cancer is due to the proteins the sex hormones bind to. Specifically a group of proteins called Foxa 1 and 2.

Study findings were published in the medical journal Cell.

In past studies, when lab mice were given a liver carcinogen, male mice grew several tumors, while females grew only a small amount, however, these results were reversed when scientists removed the Foxa gene after they induced the mice with cancer, and showed that the actions of both estrogens and androgens in the liver are Foxa dependent, which explains the reversed cancer results among the different gender of mice.

Although results of this experiment were informative, a different approach would be needed by researchers to asses the liver cancer risks among humans, as there are 5,000 different places in the human DNA where Foxa factors can attach themselves.

They looked for specific genetic genetic markers called SNP’s, which is a DNA sequence variation that occurs when a single DNA building block differs amongst members of a biological species, or “paired chromosomes in an individual, according to what the authors wrote.

Since researchers already knew that in women the estrogen receptor protects against liver cancer, they look for SNP markers within Foxa binding sites in tissue samples from those who did and didn’t have liver cancer.

They found that women with liver cancer frequently had SNP’s within specific Foxa binding sites, and proved that mutated SNP acts not only to abolish binding of the Foxa proteins, but also of the estrogen receptor to its main sites, thus decreasing the risk of liver cancer.

More from AM 1240 KLYQ

Best of the Web

It appears that you already have an account created within our VIP network of sites on . To keep your points and personal information safe, we need to verify that it's really you. To activate your account, please confirm your password. When you have confirmed your password, you will be able to log in through Facebook on both sites.

Forgot your password?

*Please note that your points, prizes and activities will not be shared between programs within our VIP network.

It appears that you already have an account on this site associated with . To connect your existing account with your Facebook account, just click on the account activation button below. You will maintain your existing profile and VIP program points. After you do this, you will be able to always log in to http://klyq.com using your Facebook account.

*Please note that your points, prizes and activities will not be shared between programs within our VIP network.

Please fill out the information below to help us provide you a better experience.

Register on AM 1240 KLYQ quickly by logging in with your Facebook account. It's just as secure, and no password to remember!

Not a Member? Sign Up Here.

Sign up for an account to comment, share your thoughts, and earn points to get great prizes.

Register on AM 1240 KLYQ quickly by logging in with your Facebook account. It's just as secure, and no password to remember!