Rocky Mountain Labs Contribute to Ebola Vaccine Breakthrough
A study at Hamilton's Rocky Mountain Laboratories shows that an experimental Ebola vaccine protects monkeys from various strains of the deadly Ebola virus.
Principal author of the study, Andrea Marzi, Ph.D, worked with a vaccine developed by Dr. Heinz Feldmann, M.D., Ph.D, and Thomas Geisbert. In her paper, Marzi reported the vaccine was safe and effective, and even better, appeared to trigger adaptive immunity in macaque monkeys with a single dose. The vaccine completely protected the monkeys if given at least seven days before infection and partially protected them if given three days before infection, according to the news release from the National Institute of Allergy and Infectious Diseases.
Marzi's article was published in "Science." The title is "VSV-EBOV rapidly protects macaques against infection with the 2014-15 Ebola virus outbreak strain." Other authors in the article were: Shelly J. Robertson, Elaine Haddock, Friederike Feldmann,
Patrick W. Hanley, Dana P. Scott, James E. Strong, Gary Kobinger, Sonja M. Best, Heinz Feldmann.
The same vaccine was used in a successful human clinical trial in Guinea, according to Public Affairs Officer Ken Pekoc at RML.